Program

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Thursday, 3rd June

12:30 Opening and Welcome Addresses

13:30 Keynote

• Denis Noble - University of Oxford, UK:
  • Principles of systems biology and their application to cells

14:15 New approaches and cutting edge technologies

• Denis Thieffry - Université de la Méditerranée, France:
  • Diversity and plasticity of t-helper cell types predicted from regulatory network modelling
• William Senapedis - Harvard Medical School, USA:
  • A nuclear localization switchable davice reveals a regulatory network
• Andre Levchenko - Johns Hopkins University, USA:
  • Understanding the limits of Information processing in signaling pathways through combination of modeling and experimentation
• Andrius Serva – BioQuant, Germany:
  • Functional analysis of microRNAs as regulators of secretory membrane trafficking
• Jan Hasenauer – University of Stuttgart, Germany:
  • Single cells vs. cell populations - From a binary decision to a continuous response
• Martin Fussenegger - ETH Zurich, Switzerland:
  • Mammalian synthetic biology: from tools to therapies
• Forest M. White - Massachusetts Institute of Technology, USA:
  • Biological insights from quantitative analysis of receptor tyrosine kinase signaling networks

18.00 Excursion by historic train to a vineyard in the Kaiserstuhl region

Friday, 4th June

9:00 Signaling

• H. Steven Wiley - Pacific Northwest National Laboratory, USA:
  • Reconstructing Signaling Networks by Integrating Quantitative Proteomic and Genomic Data
• Joseph Zhou – Technical University Dresden, Germany:
  • Predicting pancreas cell fate decisions and reprogramming with a hierarchical multi-attractor model
• Jason M. Haugh - North Carolina State University, USA:
  • Dynamic Regulation of Growth Factor Receptor Signaling Networks
• Tilo Beyer – Otto-von-Guericke University, Germany:
  • Integrating signals from T-cell receptors and the Interleukin-2 receptor
• Michael Yaffe - Massachusetts Institute of Technology, USA:
  • Systems Biology of the DNA Damage Response: Implications for Rational Design of Cancer Therapy
• Pernette Verschure - University of Amsterdam, The Netherlands:
  • Epigenetic gene regulation of the eukaryotic genome: Systems Biology approaches using synthetic cell systems
• Michael White - University of Liverpool, UK:
  • Spatial and temporal information encoding by the NF-κB
• Verena Becker – German Cancer Research Center, Germany:
  • Covering a broad dynamic range - information processing at the Erythropoietin receptor level
• Carsten Carlberg - Université du Luxembourg, Luxembourg:
  • Systems Biology of Nuclear Receptors: The Impact of Transcriptional Cycling

14:00 MTZ Awards

• Stefan Legewie - DKFZ Heidelberg, Germany
  • Transcription Feedback Regulation of Signal Transduction
• Thomas Maiwald - Harvard Medical School, USA
  • Dynamical Modeling of Biological Systems
• Edda G. Schulz - Institut Curie, Paris, France:
  • Two positive feedback loops control effector function and memory induction in type 1 T-helper lymphocytes

15:30 Metabolism

• Hermann-Georg Holzhütter - Charité - Universitätsmedizin Berlin, Germany:
  • Mathematical Modelling of Liver Metabolism
• Christian A. Tiemann - Eindhoven University of Technology, The Netherlands:
  • A computational model of hepatic lipid metabolism: identifying persistent behavior
• Damjana Rozman - University of Ljubljana, Slovenia:
  • The cross-talk of the hepatic cholesterol and drug metabolism transcriptome
• Gunnar Cedersund - Linköping University, Sweden:
  • Combined top-down and bottom-up modelling provides internally consistent explanations of whole-body glucose homeostasis through the identification and elimination of data inconsistencies and missing regulations
• Deok-Sun Lee - Inha University, Korea:
  • Networking Metabolites, Diseases and Drugs

17:30 Poster Session I

20.00 Conference dinner at Schlossbergrestaurant Dattler

Saturday, 5th June

9:00 Biomedicine

• Walter Kolch - University College Dublin, Ireland:
  • Systems properties of the ERK pathway as negative feedback amplifier
• Niels Grabe - BioQuant, Germany:
  • Quantification of Cell Streams in Epidermal Wound Healing using a 3D in vitro Culture Model of Human Skin and whole-slide imaging
• Nils Bluethgen – Charité – Universitätsmedzin Berlin, Germany:
  • How do cancer cells escape from targeted intervention?
• Lars Kaderali - BioQuant, Germany:
  • Systems biology of hepatitis C virus replication

11:00 Whole Body Models

• Claudio Cobelli - University of Padova, Italy
  • Minimal and Maximal Models of Glucose Metabolism in Health and Diabetes
• Stefan Hoehme - University of Leipzig, Germany:
  • Cell alignment along microvessels as order principle to restore tissue architecture during liver regeneration: From experiment to virtual tissues and back
• Jörg Lippert - Bayer Technology Services GmbH, Germany:
  • Applying Computational Systems Biology to Pharmaceutical R&D
• Jens Reich - MDC Berlin, Germany:
  • Iron Regulation in the intact Organism - Kinetic Description of the Pathway Network
• Richard Ho - Entelos, Inc., USA:
  • DILI –sim: A Systems Model of the Liver Allowing Perturbations by Xenobiotics in Multiple Species

12:45 Poster Session II

15:00 Industry

• Birgit Schöberl - Merrimack Pharmaceuticals, Inc., USA:
  • Applying engineering principles to develop novel therapies
• Christopher Taylor - AstraZeneca, UK:
  • Applying Systems Biology in Drug Discovery
• Sean Ekins - Collaborations in Chemistry, Inc., USA:
  • Toxicity Pathways and Models: Mining for potential off-target effects

17:15 End of Conference